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J Ethnopharmacol. 2015 Jul 1;169:239-43. doi: 10.1016/j.jep.2015.04.038. Epub 2015 Apr 28.

Effects of Cydonia oblonga Miller leaf and fruit flavonoids on blood lipids and anti-oxydant potential in hyperlipidemia rats.

Author information

1
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France. Electronic address: Anwar.umar@126.com.
2
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China.
3
Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China.
4
Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France.
5
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France.
6
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France; Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China. Electronic address: nicholas.moore@pharmaco.u-bordeaux2.fr.

Abstract

OBJECTIVE:

To study the effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials using hyperlipidaemic rat models.

METHODS:

Hyperlipidaemic rat models were created with high-lipid emulsion. Rats were distributed into normal controls, hyperlipidaemic models, and daily high (160mg/kg), medium (80mg/kg) and low (40mg/kg) TF from leaves and fruit and simvastatin (5mg/kg) groups. After four weeks, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), as well as hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured.

RESULTS:

Compared with the hyperlipidaemic model group, TF significantly reduced serum TC, TG, LDL-C (P<0.01), ALT and AST (P<0.01 or P<0.05) and increased HDL-C (P<0.05 or P<0.01). TF also reduced MDA (P<0.01 or P<0.01).

CONCLUSION:

COM total flavonoids can effectively regulate the metabolism of lipids, and remove oxygen free radicals. This confirms its potential value in the prevention and treatment of hyperlipidaemia.

KEYWORDS:

Antioxidant effect; Blood lipids; Cydonia oblonga miller; Hyperlipidemic rats; Oxygen free radicals

PMID:
25934516
DOI:
10.1016/j.jep.2015.04.038
[Indexed for MEDLINE]

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