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Int J Pharm. 2015 Jul 15;489(1-2):100-5. doi: 10.1016/j.ijpharm.2015.04.068. Epub 2015 Apr 28.

Estimation of Young's modulus of pharmaceutical tablet obtained by terahertz time-delay measurement.

Author information

1
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland. Electronic address: kai.peiponen@uef.fi.
2
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
3
Photonics Devices and Measurement Solutions, VTT Technical Research Center of Finland, Kuopio, Finland.
4
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom.
5
School of Pharmacy, Promis Centre, University of Eastern Finland, P. O. Box 1617, FI-70211, Kuopio, Finland.

Abstract

In this paper, it is suggested that Young's modulus of pharmaceutical tablets with different porosity can be estimated from terahertz (THz) pulse time delay. We demonstrate such a possibility using a training set of tablets compressed from starch acetate. Once the mechanical properties are taught to the THz measurement system, using an ideal tablet as a reference, it is possible to get information about the Young's modulus of the tablet. Here, we show that there are optical counterparts of classical mechanical laws that couple the Young's modulus and porosity of the tablet.

KEYWORDS:

Pharmaceutical tablet; Porosity; Refractive index; Spriggs law; Terahertz pulse; Young’s modulus

PMID:
25934425
DOI:
10.1016/j.ijpharm.2015.04.068
[Indexed for MEDLINE]

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