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Ann Endocrinol (Paris). 2015 Jul;76(3):253-9. doi: 10.1016/j.ando.2015.03.008. Epub 2015 Apr 28.

The history of Distilbène® (Diethylstilbestrol) told to grandchildren--the transgenerational effect.

Author information

1
Endocrinology-Diabetology and Reproduction Unit/Inserm U1065-C3M, Nice University Hospital, Nice, France. Electronic address: fenichel.p@chu-nice.fr.
2
Endocrinology-Diabetology and Reproduction Unit/Inserm U1065-C3M, Nice University Hospital, Nice, France.

Abstract

The Distilbène® story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications.

KEYWORDS:

Adénocarcinome vaginal; Distilbène(®); Effet transgénérationnel; Endocrine disruptors; Exposition fœtale; Fetal exposure; Hypospadias; Perturbateurs endocriniens; Transgenerational effect; Vaginal adenocarcinoma

PMID:
25934356
DOI:
10.1016/j.ando.2015.03.008
[Indexed for MEDLINE]

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