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FEMS Microbiol Rev. 2015 May;39(3):379-91. doi: 10.1093/femsre/fuv014. Epub 2015 Apr 30.

How do base-pairing small RNAs evolve?

Author information

1
Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institutes of Health, Bethesda, MD 20892, USA.
2
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
3
Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institutes of Health, Bethesda, MD 20892, USA storz@helix.nih.gov.

Abstract

The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the identification of these regulators in a broad range of bacteria are allowing comparisons between species and explorations of sRNA evolution. In this review, we describe some examples of trans-encoded base-pairing sRNAs that are species-specific and others that are more broadly distributed. We also describe examples of sRNA orthologs where different features are conserved. These examples provide the background for a discussion of mechanisms of sRNA evolution and selective pressures on the sRNAs and their mRNA target(s).

KEYWORDS:

Hfq; evolution; mosaic pattern of selective pressure; sRNAs

PMID:
25934120
PMCID:
PMC4542690
DOI:
10.1093/femsre/fuv014
[Indexed for MEDLINE]
Free PMC Article

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