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Physiology (Bethesda). 2015 May;30(3):224-31. doi: 10.1152/physiol.00021.2014.

Impact of maternal obesity on fetal programming of cardiovascular disease.

Author information

1
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and robertsv@ohsu.edu.
2
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
3
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and.

Abstract

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.

PMID:
25933822
PMCID:
PMC4422977
DOI:
10.1152/physiol.00021.2014
[Indexed for MEDLINE]
Free PMC Article

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