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Physiology (Bethesda). 2015 May;30(3):208-23. doi: 10.1152/physiol.00039.2014.

Mitochondria, muscle health, and exercise with advancing age.

Author information

1
Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
2
Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada dhood@yorku.ca.

Abstract

Skeletal muscle health is dependent on the optimal function of its mitochondria. With advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part of this decline is due to reduced physical activity, whereas the remainder appears to be attributed to age-related alterations in mitochondrial synthesis and degradation. Exercise is an important strategy to stimulate mitochondrial adaptations in older individuals to foster improvements in muscle function and quality of life.

PMID:
25933821
DOI:
10.1152/physiol.00039.2014
[Indexed for MEDLINE]
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