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J Clin Invest. 2015 May;125(5):1790-2. doi: 10.1172/JCI81507. Epub 2015 May 1.

Abdominal obesity: a marker of ectopic fat accumulation.

Abstract

In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a criterion for the diagnosis of metabolic syndrome. Several mechanisms for this relationship have been postulated; however, we now know that visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot accommodate excess fat because of its limited expandability.

PMID:
25932676
PMCID:
PMC4463217
DOI:
10.1172/JCI81507
[Indexed for MEDLINE]
Free PMC Article

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