Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2015 Jul 1;61(1):59-66. doi: 10.1093/cid/civ234. Epub 2015 Apr 29.

Swine Farming Is a Risk Factor for Infection With and High Prevalence of Carriage of Multidrug-Resistant Staphylococcus aureus.

Author information

  • 1Center for Emerging Infectious Diseases Department of Epidemiology, College of Public Health.
  • 2Center for Emerging Infectious Diseases.
  • 3Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City.
  • 4Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
  • 5Department of Epidemiology, College of Public Health.
  • 6Department of Geographical and Sustainability Sciences, College of Liberal Arts and Sciences.
  • 7Department of Biostatistics, Environmental Health Sciences and Epidemiology, College of Public Health, Kent State University, Ohio.

Abstract

BACKGROUND:

Livestock-associated Staphylococcus aureus (LA-SA) has been documented worldwide. However, much remains unknown about LA-SA colonization and infection, especially in rural environments.

METHODS:

We conducted a large-scale prospective study of 1342 Iowans, including individuals with livestock contact and a community-based comparison group. Nasal and throat swabs were collected to determine colonization at enrollment, and skin infection swabs over 17 months were assessed for S. aureus. Outcomes included carriage of S. aureus, methicillin-resistant S. aureus (MRSA), tetracycline-resistant S. aureus (TRSA), multidrug-resistant S. aureus (MDRSA), and LA-SA.

RESULTS:

Of 1342 participants, 351 (26.2%; 95% confidence interval [CI], 23.8%-28.6%) carried S. aureus. MRSA was isolated from 34 (2.5%; 95% CI, 1.8%-3.5%) and LA-SA from 131 (9.8%; 95% CI, 8.3%-11.5%) of the 1342 participants. Individuals with current swine exposure were significantly more likely to carry S. aureus (prevalence ratio [PR], 1.8; 95% CI, 1.4-2.2), TRSA (PR, 8.4; 95% CI, 5.6-12.6), MDRSA (PR, 6.1; 95% CI, 3.8-10.0), and LA-SA (PR, 5.8; 95% CI, 3.9-8.4) than those lacking exposure. Skin infections (n = 103) were reported from 67 individuals, yielding an incidence rate of 6.6 (95% CI, 4.9-8.9) per 1000 person-months.

CONCLUSIONS:

Current swine workers are 6 times more likely to carry MDRSA than those without current swine exposure. We observed active infections caused by LA-SA. This finding suggests that individuals with livestock contact may have a high prevalence of exposure to, and potentially infection with, antibiotic-resistant S. aureus strains, including LA-SA strains.

KEYWORDS:

Staphylococcus aureus; colonization; livestock-associated Staphylococcus aureus; multidrug resistance; swine

PMID:
25931444
PMCID:
PMC4481598
DOI:
10.1093/cid/civ234
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center