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Genes Chromosomes Cancer. 2015 Jul;54(7):453-62. doi: 10.1002/gcc.22257. Epub 2015 Apr 30.

Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer.

Author information

1
Department of Obstetrics and Gynecology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, 300100, China.
2
State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, China.
3
Tianjin Research Center of Basic Medical Science, Tianjin Medical University, Tianjin, 300070, China.
4
Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
5
Beijing Institute of Life Science, Chinese Academy of Science, Beijing, 100101, China.
6
Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, 100853, China.

Abstract

As a transforming growth factor-β (TGF-β)-inducible gene, the expression of Krüppel-like transcription factor 11 (KLF11) is altered in several types of cancer. In the current study, through using human 9K CpG island array, KLF11 was identified as one of hypermethylated genes in RAS-transformed ovarian T29H cells. Methylation of the KLF11 promoter was also observed in ovarian cancer tissue samples accompanied by significantly reduced KLF11 gene expression. Interestingly, the expression of SMAD2, SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF-β expression. Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis.

PMID:
25931269
DOI:
10.1002/gcc.22257
[Indexed for MEDLINE]

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