Format

Send to

Choose Destination
Pancreas. 2015 Aug;44(6):925-9. doi: 10.1097/MPA.0000000000000357.

Pancreatic Endocrine Effects of Dopamine Receptors in Human Islet Cells.

Author information

1
From the *Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing; and †School of Medicine, Nankai University, Tianjin, China.

Abstract

OBJECTIVE:

To date, there are no reports on the cellular localization of dopamine receptors in the human pancreas. In our study, we determined the localization and expression of 5 dopamine receptors (D(1), D(2), D(3), D(4), and D(5)) in normal human pancreas tissue.

METHODS:

Human nonpathological pancreas tissues were fixed with 4% paraformaldehyde, paraffin-embedded, and processed for immunohistochemical analysis to detect dopamine receptors in the human pancreas tissue by using double immunofluorescent labeling and confocal microscopy.

RESULTS:

We found that the D(1) receptor is present in β cells; the D(2) receptor is expressed by α, δ, and pancreatic polypeptide cells; the D(4) receptor is expressed by β and polypeptide cells; whereas the D(5) receptor is expressed only by δ cells.

CONCLUSIONS:

Our results identify the dopamine receptors (D(1)-D(5)) in normal pancreas tissue and provide a morphological basis for studying the pancreatic endocrine effects of dopamine and suggest a new target for the clinical treatment of diabetes.

PMID:
25931261
DOI:
10.1097/MPA.0000000000000357
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center