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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Apr;40(4):438-45. doi: 10.11817/j.issn.1672-7347.2015.04.017.

[Expression of 5-lipoxygenase in human tissues and its association with disease].

[Article in Chinese]

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1
Department of Occupational and Environmental Health, School of Public Health, Central South University, Changsha 410078, China.

Abstract

5-Lipoxygenase, one of lipoxygenase isozymes, is a well-studied oxidative metabolism enzyme. It widely exists in various human tissues and cells, participates in the oxidative metabolism of endogenous and exogenous chemicals, and produces a variety of metabolites, all of which contribute to the occurrence of human diseases, such as inflammation, asthma, atherosclerosis, and tumor and so on. The expression of 5-lipoxygenase is at low level in normal human tissues while at high level in abnormal tissues. 5-Lipoxygenase is closely related to many kinds of diseases in human ovary, brain, cardiovascular system, lung, liver, pancreas and other tissues. The abnormal expression of 5-lipoxygenase tends to promote the development of the disease.

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