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Diabetes Obes Metab. 2015 Aug;17(8):800-4. doi: 10.1111/dom.12481. Epub 2015 Jun 4.

Effects of luseogliflozin, a sodium-glucose co-transporter 2 inhibitor, on 24-h glucose variability assessed by continuous glucose monitoring in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, crossover study.

Author information

1
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
2
Naka Kinen Clinic, Ibaraki, Japan.
3
OCROM Clinic, Osaka, Japan.
4
Jinnouchi Hospital, Kumamoto, Japan.
5
Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.

Abstract

The aim of the present study was to determine the effects of luseogliflozin on 24-h glucose levels, assessed by continuous glucose monitoring, and on pharmacodynamic variables measured throughout the day. In this double-blind, placebo-controlled, crossover study, 37 patients with type 2 diabetes mellitus inadequately controlled with diet and exercise were randomized into two groups. Patients in each group first received luseogliflozin then placebo for 7 days each, or vice versa. After 7 days of treatment, the mean 24-h glucose level was significantly lower with luseogliflozin than with placebo [mean (95% confidence interval) 145.9 (134.4-157.5) mg/dl vs 168.5 (156.9-180.0) mg/dl; p < 0.001]. The proportion of time spent with glucose levels ≥70 to ≤180 mg/dl was significantly greater with luseogliflozin than with placebo [median (interquartile range) 83.2 (67.7-96.5)% vs 71.9 (46.9-83.3)%; p < 0.001] without inducing hypoglycaemia. The decrease in glucose levels was accompanied by reductions in serum insulin levels throughout the day.

KEYWORDS:

24-h glucose variability; SGLT2 inhibitor; continuous glucose monitoring; luseogliflozin; type 2 diabetes

PMID:
25930989
PMCID:
PMC5032984
DOI:
10.1111/dom.12481
[Indexed for MEDLINE]
Free PMC Article

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