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Mol Nutr Food Res. 2015 Aug;59(8):1629-34. doi: 10.1002/mnfr.201400885. Epub 2015 May 28.

Physiological relevance of food grade microcapsules: Impact of milk protein based microcapsules on inflammation in mouse models for inflammatory bowel diseases.

Author information

1
Chair for Food Process Engineering and Dairy Technology, ZIEL Institute for Food and Health, Technische Universität München, Freising-Weihenstephan, Germany.
2
Chair of Nutrition and Immunology, ZIEL Institute for Food and Health, Technische Universität München, Freising-Weihenstephan, Germany.
3
Junior Research Group Intestinal Microbiome, ZIEL Institute for Food and Health, Technische Universität München, Freising-Weihenstephan, Germany.
4
Chair of Process Engineering of Disperse Systems, Technische Universität München, Freising-Weihenstephan, Germany.

Abstract

In order to increase beneficial effects of bioactive compounds in functional food and dietary supplements, enormous efforts are put in the technological development of microcapsules. Although these products are often tailor-made for disease susceptible consumer, the physiological impact of microcapsule uptake on the respective target consumer has never been addressed. The present study aimed to assess the relevance of this aspect by analyzing the impact of milk protein based microcapsules on experimental inflammatory bowel disease. Long-term feeding of sodium caseinate or rennet gel microcapsules resulted in significant alterations in the intestinal microbiota of healthy mice. In TNFΔARE/wt mice, a model for chronic ileal inflammation, rennet gel microcapsules resulted in further increased splenomegaly, whereas ileal inflammation was unchanged. In IL10(-/-) mice, a model for chronic colitis, both types of microcapsules induced a local increase of the intestinal inflammation. The present study is the first to demonstrate that, independent of their cargo, microcapsules have the potential to affect the intestinal microbiota and to exert unprecedented detrimental effects on disease-susceptible individuals. In conclusion, the impact of microcapsule uptake on the respective target consumer groups should be thoroughly investigated in advance to their commercial use in functional food or dietary supplements.

KEYWORDS:

Functional food; IBD; Intestinal microbiota; Microencapsulation; Probiotics

PMID:
25929669
DOI:
10.1002/mnfr.201400885
[Indexed for MEDLINE]

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