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Br J Cancer. 2015 May 26;112(11):1805-15. doi: 10.1038/bjc.2014.599. Epub 2015 Apr 30.

Stomach cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies.

Author information

1
MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.

Abstract

BACKGROUND:

A recent Monographs Working Group of the International Agency for Research on Cancer concluded that there is limited evidence for a causal association between exposure to asbestos and stomach cancer.

METHODS:

We performed a meta-analysis to quantitatively evaluate this association. Random effects models were used to summarise the relative risks across studies. Sources of heterogeneity were explored through subgroup analyses and meta-regression.

RESULTS:

We identified 40 mortality cohort studies from 37 separate papers, and cancer incidence data were extracted for 15 separate cohorts from 14 papers. The overall meta-SMR for stomach cancer for total cohort was 1.15 (95% confidence interval 1.03-1.27), with heterogeneous results across studies. Statistically significant excesses were observed in North America and Australia but not in Europe, and for generic asbestos workers and insulators. Meta-SMRs were larger for cohorts reporting a SMR for lung cancer above 2 and cohort sizes below 1000.

CONCLUSIONS:

Our results support the conclusion by IARC that exposure to asbestos is associated with a moderate increased risk of stomach cancer.

PMID:
25928706
PMCID:
PMC4647249
DOI:
10.1038/bjc.2014.599
[Indexed for MEDLINE]
Free PMC Article

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