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BMC Psychiatry. 2015 May 1;15:94. doi: 10.1186/s12888-015-0477-y.

Effects of ECT in treatment of depression: study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function.

Author information

1
Department of Radiology, Haukeland University Hospital, Bergen, Norway. leif.oltedal@k1.uib.no.
2
Department of Clinical Medicine, University of Bergen, Bergen, Norway. leif.oltedal@k1.uib.no.
3
Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. ute.kessler@helse-bergen.no.
4
Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway. lars.ersland@helse-bergen.no.
5
Department of Radiology, Haukeland University Hospital, Bergen, Norway. renate@fmri.no.
6
NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway. o.a.andreassen@medisin.uio.no.
7
K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway. Jan.Haavik@biomed.uib.no.
8
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. per.ivar.hoff@helse-bergen.no.
9
Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. aasa.Hammar@uib.no.
10
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway. aasa.Hammar@uib.no.
11
Departments of Neurosciences, Radiology and Psychiatry, University of California, San Diego, CA, USA. andersmdale@gmail.com.
12
Multimodal Imaging Laboratory, University of California, San Diego, CA, USA. andersmdale@gmail.com.
13
Department of Radiology, Haukeland University Hospital, Bergen, Norway. Hugdahl@psybp.uib.no.
14
Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. Hugdahl@psybp.uib.no.
15
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway. Hugdahl@psybp.uib.no.
16
Department of Clinical Medicine, University of Bergen, Bergen, Norway. ketil.odegaard@helse-bergen.no.
17
Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. ketil.odegaard@helse-bergen.no.
18
K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway. ketil.odegaard@helse-bergen.no.

Abstract

BACKGROUND:

Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ECT has shown efficacy in randomized controlled trials, the treatment is still controversial and stigmatized. This can in part be attributed to our lack of knowledge of the mechanisms of action. Some reports also suggest potential harmful effects of ECT treatment and memory related side effects have been documented.

METHODS/DESIGN:

The present study will apply state of the art radiology through advanced magnetic resonance imaging (MRI) techniques to investigate structural and functional brain effects of ECT. As a multi-disciplinary collaboration, imaging findings will be correlated to psychiatric response parameters, neuropsychological functioning as well as neurochemical and genetic biomarkers that can elucidate the underlying mechanisms. The aim is to document both treatment effects and potential harmful effects of ECT.

SAMPLE:

n = 40 patients in a major depressive episode (bipolar and major depressive disorder). Two control groups with n = 15 in each group: age and gender matched healthy volunteers not receiving ECT and patients undergoing electrical cardioversion (ECV) for atrial fibrillation (AF). Observation time: six months.

DISCUSSION:

The study will contribute to our understanding of the pathophysiology of major depression as well as mechanisms of action for the most effective treatment for the disorder; ECT.

PMID:
25927716
PMCID:
PMC4422607
DOI:
10.1186/s12888-015-0477-y
[Indexed for MEDLINE]
Free PMC Article

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