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BMC Infect Dis. 2014 Dec 10;14:635. doi: 10.1186/s12879-014-0635-8.

Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network).

Author information

1
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. valentina.picot@fondation-merieux.org.
2
Infection Control and Epidemiology Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. thomas.benet@chu-lyon.fr.
3
Epidemiology and Public Health Unit, University of Lyon 1, Lyon, France. thomas.benet@chu-lyon.fr.
4
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. melina.messaoudi@fondation-merieux.org.
5
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. jean-noel.telles@fondation-merieux.org.
6
Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia. cmonidarin@uhs.edu.kh.
7
Department of Pneumology, National Pediatric Hospital, Phnom Penh, Cambodia. techheng@yahoo.com.
8
MOH Key Laboratory of Systems Biology of Pathogens and Dr. Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College), Beijing, China. wangjw28@163.com.
9
Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China. kunlingshen1717@163.com.
10
GHESKIO (Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers, Port au Prince, Haiti. jwpape@gheskio.org.
11
GHESKIO (Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers, Port au Prince, Haiti. vrouzier@gheskio.org.
12
Chatrapati Shahuji Maharaj University, Lucknow, India. shally07@gmail.com.
13
Chatrapati Shahuji Maharaj University, Lucknow, India. drnitinpandey@gmail.com.
14
KEM Hospital Research Center, Pune, India. bavdekar@vsnl.com.
15
KEM Hospital Research Center, Pune, India. sanghsk@yahoo.com.
16
Hôpital Femme-Mère-Enfant, Antananarivo, Madagascar. annicklalaina@yahoo.fr.
17
Fondation Mérieux, Centre d'Infectiologie Charles Mérieux (CICM), Antananarivo, Madagascar. benedicte.contamin@fondation-merieux.org.
18
Fondation Mérieux, Centre d'Infectiologie Charles Mérieux (CICM), Antananarivo, Madagascar. jonathan.hoffmann@fondation-merieux.org.
19
Gabriel Touré Hospital, Bamako, Mali. dr_mame@yahoo.fr.
20
Centre d'Infectiologie Charles Mérieux (CICM), Bamako, Mali. souleymane.diallo@fondationmerieux-mali.org.
21
Mongolian Academy of Medical Sciences, Ulaanbaatar, Mongolia. nymadawa@gyals.mn.
22
Bayanzurkh District General Hospital, Ulaanbaatar, Mongolia. dashyandag@mobinet.mn.
23
Research Institute of Health, Asuncion, Paraguay. grusso@rieder.net.py.
24
Hospital Pediátrico "Niños de Acosta Ñu", San Lorenzo, Paraguay. wilmabasualdo@gmail.com.
25
Respiratory virus Laboratory, Oswaldo Cruz Foundation, Hospital Bonsucesso, Rio de Janeiro, Brazil. mmsiq@ioc.fiocruz.br.
26
Respiratory virus Laboratory, Oswaldo Cruz Foundation, Hospital Bonsucesso, Rio de Janeiro, Brazil. pfbcosta@gmail.com.
27
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. florence.pradel@fondation-merieux.org.
28
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. guy.vernet@hotmail.com.
29
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. hubert.endtz@fondation-merieux.org.
30
Infection Control and Epidemiology Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. philippe.vanhems@chu-lyon.fr.
31
Epidemiology and Public Health Unit, University of Lyon 1, Lyon, France. philippe.vanhems@chu-lyon.fr.
32
Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France. glaucia.baccala@fondation-merieux.org.

Abstract

BACKGROUND:

Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia.

METHODS/DESIGN:

A multicenter case-control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples.

DISCUSSION:

This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.

PMID:
25927410
PMCID:
PMC4272811
DOI:
10.1186/s12879-014-0635-8
[Indexed for MEDLINE]
Free PMC Article

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