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Complement Ther Clin Pract. 2015 May;21(2):61-7. doi: 10.1016/j.ctcp.2015.04.001. Epub 2015 Apr 18.

Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. A randomized, placebo-controlled, trial.

Author information

1
Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: shakibaei@med.mui.ac.ir.
2
Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: mehrsa.radmanesh@gmail.com.
3
Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: elsalari@yahoo.com.
4
Department of Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: behzad.mahaki@gmail.com.

Abstract

OBJECTIVE:

To evaluate the efficacy of Ginkgo biloba as a complementary therapy for attention-deficit/hyperactivity disorder (ADHD).

METHODS:

Children and adolescents with ADHD received methylphenidate (20-30 mg/day) plus either G. biloba (80-120 mg/day) or placebo for 6 weeks. Parent and teacher forms of the ADHD Rating Scale-IV (ADHD-RS-IV) were completed at baseline, week 2, and week 6. Treatment response was defined as 27% improvement from baseline in the ADHD-RS-IV.

RESULTS:

Compared with placebo, more reduction was observed with G. biloba regarding ADHD-RS-IV parent rating inattention score (-7.74 ± 1.94 vs. -5.34 ± 1.85, P < 0.001) and total score (-13.1 ± 3.36 vs. -10.2 ± 3.01, P = 0.001) as well as teacher rating inattention score (-7.29 ± 1.90 vs. -5.96 ± 1.52, P = 0.004). Response rate was higher with G. biloba compared with placebo based on parent rating (93.5% vs. 58.6%, P = 0.002).

CONCLUSIONS:

The G. biloba is an effective complementary treatment for ADHD. Further studies with longer treatment duration are warranted in this regard. IRCT2014111519958N1.

KEYWORDS:

Attention deficit disorder with hyperactivity; Complementary therapies; Ginkgo biloba; Herbal medicine; Methylphenidate

PMID:
25925875
DOI:
10.1016/j.ctcp.2015.04.001
[Indexed for MEDLINE]

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