Format

Send to

Choose Destination
J Neuroendocrinol. 2015 Jun;27(6):389-98. doi: 10.1111/jne.12287.

5-hydroxytryptamine medications for the treatment of obesity.

Author information

1
Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
2
Department of Pharmacology, University of Cambridge, Cambridge, UK.

Abstract

The central 5-hydroxytryptamine (5-HT; serotonin) system represents a fundamental component of the brain's control of energy homeostasis. Medications targeting the 5-HT pathway have been at the forefront of obesity treatment for the past 15 years. Pharmacological agents targeting 5-HT receptors (5-HTR), in combination with genetic models of 5-HTR manipulation, have uncovered a role for specific 5-HTRs in energy balance and reveal the 5-HT2 C R as the principal 5-HTR mediating this homeostatic process. Capitalising on this neurophysiological machinery, 5-HT2 C R agonists improve obesity and glycaemic control in patient populations. The underlying therapeutic mechanism has been probed using model systems and appears to be achieved primarily through 5-HT2 C R modulation of the brain melanocortin circuit via activation of pro-opiomelanocortin neurones signalling at melanocortin4 receptors. Thus, 5-HT2 C R agonists offer a means to improve obesity and type 2 diabetes, which are conditions that now represent global challenges to human health.

KEYWORDS:

5-HT2CR; lorcaserin; obesity; serotonin; type 2 diabetes

PMID:
25925636
DOI:
10.1111/jne.12287
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center