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PLoS Biol. 2015 Apr 29;13(4):e1002131. doi: 10.1371/journal.pbio.1002131. eCollection 2015 Apr.

Why is aging conserved and what can we do about it?

Author information

1
Department of Pathology, University of Washington, Seattle, Washington, United States of America.

Abstract

The field of aging research has progressed rapidly over the past few decades. Genetic modulators of aging rate that are conserved over a broad evolutionary distance have now been identified. Several physiological and environmental interventions have also been shown to influence the rate of aging in organisms ranging from yeast to mammals. Here we briefly review these conserved pathways and interventions and highlight some key unsolved challenges that remain. Although the molecular mechanisms by which these modifiers of aging act are only partially understood, interventions to slow aging are nearing clinical application, and it is likely that we will begin to reap the benefits of aging research prior to solving all of the mysteries that the biology of aging has to offer.

PMID:
25923592
PMCID:
PMC4414409
DOI:
10.1371/journal.pbio.1002131
[Indexed for MEDLINE]
Free PMC Article

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