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Nat Prod Res. 2015;29(12):1166-9. doi: 10.1080/14786419.2014.981812. Epub 2015 Apr 29.

Spermicidal activity of the hexane extract of Piper longum: an in vitro study.

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a Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia , New Delhi 110025 , India.


This study was carried out to assess the spermicidal action of hexane extract from the fruits of Piper longum Linn. The sperm immobilisation studies showed that 20 mg/mL of hexane extract was able to immobilise sperms completely within 20 s. The sperm revival test revealed that the effects were spermicidal as sperm immobilisation effect was irreversible. There was also a significant reduction in sperm viability in the treated group in comparison to the control. The hypo-osmotic swelling of these sperms was significantly reduced, indicating that the hexane extract may probably cause injury to the sperm plasma membrane. Hence, this study showed that the hexane extract of P. longum possesses potential contraceptive spermicidal activity in vitro.


Piper longum; contraceptive; spermicidal

[Indexed for MEDLINE]

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