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Trends Genet. 2015 Jun;31(6):307-15. doi: 10.1016/j.tig.2015.03.011. Epub 2015 Apr 25.

When bigger is better: the role of polyploidy in organogenesis.

Author information

1
Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: weaver@wi.mit.edu.

Abstract

Defining how organ size is regulated, a process controlled not only by the number of cells but also by the size of the cells, is a frontier in developmental biology. Large cells are produced by increasing DNA content or ploidy, a developmental strategy employed throughout the plant and animal kingdoms. The widespread use of polyploidy during cell differentiation makes it important to define how this hypertrophy contributes to organogenesis. I discuss here examples from a variety of animals and plants in which polyploidy controls organ size, the size and function of specific tissues within an organ, or the differentiated properties of cells. In addition, I highlight how polyploidy functions in wound healing and tissue regeneration.

KEYWORDS:

cell cycle; development; endocycle; endomitosis; endoreduplication

PMID:
25921783
PMCID:
PMC4537166
DOI:
10.1016/j.tig.2015.03.011
[Indexed for MEDLINE]
Free PMC Article

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