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Invest Radiol. 1989 Jun;24 Suppl 1:S16-22.

Reproductive, developmental, and genetic toxicology of ioversol.

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  • 1Pharmaceutical R & D Division, Mallinckrodt Medical, Inc., St. Louis, Missouri.


The authors examined the reproductive, developmental, and genetic toxicity of ioversol in several in vivo and in vitro systems. In Segments I, II, and III reproductive toxicity studies, ioversol did not produce teratogenic effects in either rats or rabbits at daily intravenous dose levels of up to 3.2 g I/kg/day. Daily intravenous injections in male and female rats did not adversely affect fertility or reproductive function. Offspring derived from dams treated with ioversol also developed and reproduced in a normal fashion. Four genetic toxicity studies employing bacterial and mammalian assay systems, and using both in vitro and in vivo methods, indicated that ioversol did not possess mutagenic or clastogenic activity.

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