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Cell Rep. 2015 May 5;11(5):770-84. doi: 10.1016/j.celrep.2015.03.067. Epub 2015 Apr 23.

Innate and adaptive immune functions of peyer's patch monocyte-derived cells.

Author information

1
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, 13288 Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France.
2
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, 13288 Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France. Electronic address: lelouard@ciml.univ-mrs.fr.

Abstract

Peyer's patches (PPs) are primary inductive sites of mucosal immunity. Defining PP mononuclear phagocyte system (MPS) is thus crucial to understand the initiation of mucosal immune response. We provide a comprehensive analysis of the phenotype, distribution, ontogeny, lifespan, function, and transcriptional profile of PP MPS. We show that monocytes give rise to macrophages and to lysozyme-expressing dendritic cells (LysoDCs), which are both involved in particulate antigen uptake, display strong innate antiviral and antibacterial gene signatures, and, upon TLR7 stimulation, secrete IL-6 and TNF, but neither IL-10 nor IFNγ. However, unlike macrophages, LysoDCs display a rapid renewal rate, strongly express genes of the MHCII presentation pathway, and prime naive helper T cells for IFNγ production. Our results show that monocytes differentiate locally into LysoDCs and macrophages, which display distinct features from their adjacent villus counterparts.

PMID:
25921539
DOI:
10.1016/j.celrep.2015.03.067
[Indexed for MEDLINE]
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