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Mult Scler. 2015 Jun;21(7):845-53. doi: 10.1177/1352458515572406. Epub 2015 Apr 28.

Demographic and clinical features of neuromyelitis optica: A review.

Author information

1
KS Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India panditmng@gmail.com.
2
Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, and Department of Neurology, Vejle Hospital, Denmark.
3
Prasat Neurological Institute Bangkok, Thailand.
4
Department of Clinical Neurology, Oxford University Hospitals, Oxford, UK.
5
Neuro Cure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany.
6
Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
7
Department of Neurology, Brigham and Women's Hospital and Massachusetts General Hospital, Boston, USA.

Abstract

The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.

KEYWORDS:

NMO; demographics; epidemiology; incidence; prevalence

PMID:
25921037
PMCID:
PMC4463026
DOI:
10.1177/1352458515572406
[Indexed for MEDLINE]
Free PMC Article

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