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J Cardiovasc Transl Res. 2015 Jun;8(4):269-77. doi: 10.1007/s12265-015-9626-4. Epub 2015 Apr 29.

2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.

Author information

1
Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, 53226, WI, USA, mflister@mcw.edu.

Abstract

The rat has long been a key physiological model for cardiovascular research, most of the inbred strains having been previously selected for susceptibility or resistance to various cardiovascular diseases (CVD). These CVD rat models offer a physiologically relevant background on which candidates of human CVD can be tested in a more clinically translatable experimental setting. However, a diverse toolbox for genetically modifying the rat genome to test molecular mechanisms has only recently become available. Here, we provide a high-level description of several strategies for developing genetically modified rat models of CVD.

PMID:
25920443
PMCID:
PMC4475456
DOI:
10.1007/s12265-015-9626-4
[Indexed for MEDLINE]
Free PMC Article

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