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Hum Toxicol. 1989 Nov;8(6):501-6.

The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).

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1
School of Biological Sciences, National Institute for Higher Education, Dublin, Ireland.

Abstract

1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.

PMID:
2591993
[Indexed for MEDLINE]

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