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J Pediatr. 2015 May;166(5):1175-1180.e1. doi: 10.1016/j.jpeds.2015.01.055.

The Association of Vitamin D Status with Acute Respiratory Morbidity in Preterm Infants.

Author information

1
Department of Neonatology, National Maternity Hospital, Dublin, Ireland; Department of Endocrinology, Children's University Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
2
Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
3
Department of Endocrinology, Children's University Hospital, Dublin, Ireland.
4
Centre for Support and Training in Analysis and Research, School of Public Health, Physiotherapy, and Population Science, University College Dublin, Dublin, Ireland.
5
Department of Neonatology, National Maternity Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Pediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland.
6
Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.
7
School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.
8
Department of Neonatology, National Maternity Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Pediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Neonatology, Our Lady's Children's Hospital, Dublin, Ireland; Department of Pediatrics, Trinity College, Dublin, Ireland. Electronic address: elesean@hotmail.com.

Abstract

OBJECTIVE:

To assess the association between serum 25-hydroxyvitamin D (25OHD) levels and outcomes in preterm infants (<32 weeks gestation).

STUDY DESIGN:

Serum 25OHD was measured in mothers and their infants within 24 hours of birth, before the start of enteral vitamin D supplementation, and at discharge from the neonatal intensive care unit. We evaluated the associations between vitamin D status and various early preterm outcomes.

RESULTS:

Ninety-four preterm infants and their mothers were included; 92% of the infants had a 25OHD level≤50 nmol/L (20 ng/mL), and 64% had a 25OHD level<30 nmol/L (12 ng/mL). A low 25OHD level (<30 nmol/L) in preterm infants at birth was associated with increased oxygen requirement (P=.008), increased duration of intermittent positive-pressure ventilation during resuscitation at delivery (P=.032), and greater need for assisted ventilation (P=.013).

CONCLUSION:

We observed a high prevalence of low 25OHD (<30 nmol/L), and found an association between vitamin D status and acute respiratory morbidity in preterm infants after birth.

PMID:
25919726
DOI:
10.1016/j.jpeds.2015.01.055
[Indexed for MEDLINE]

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