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PLoS One. 2015 Apr 28;10(4):e0123547. doi: 10.1371/journal.pone.0123547. eCollection 2014.

Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004.

Author information

1
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas- Houston School of Public Health, Houston, TX, United States of America; Division of Urology, University of Texas- Houston Medical School, Houston, TX, United States of America.
2
Division of Urology, University of Texas- Houston Medical School, Houston, TX, United States of America.
3
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
4
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas- Houston School of Public Health, Houston, TX, United States of America.
5
Department of Epidemiology, University of Texas- MD Anderson Cancer Center, Houston, TX, United States of America.
6
Division of Biostatistics, University of Texas- Houston School of Public Health, Houston, TX, United States of America.

Abstract

OBJECTIVES:

Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED.

MATERIAL AND METHOD:

Data were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted.

RESULTS:

We found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95% CI, 0.37-0.89; and OR: 0.61; 95% CI, 0.38-0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01).

CONCLUSION:

Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.

PMID:
25919661
PMCID:
PMC4412629
DOI:
10.1371/journal.pone.0123547
[Indexed for MEDLINE]
Free PMC Article

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