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J Am Geriatr Soc. 2015 May;63(5):938-46. doi: 10.1111/jgs.13379. Epub 2015 Apr 27.

Low Levels of a Urinary Biomarker of Dietary Polyphenol Are Associated with Substantial Cognitive Decline over a 3-Year Period in Older Adults: The Invecchiare in Chianti Study.

Author information

1
Biomarkers & Nutrimetabolomic Lab., Nutrition and Food Science Department, XaRTA, INSA, Campus Torribera, Pharmacy Faculty, University of Barcelona, Barcelona, Spain.
2
Geriatrics and Emergency Care, Italian National Research Centre on Aging, Ancona, Italy.
3
Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.
4
Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy.
5
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

Abstract

OBJECTIVES:

To investigate the association between total urinary polyphenols (TUPs) and total dietary polyphenols (TDPs) and cognitive decline in an older population.

DESIGN:

The Invecchiare in Chianti (InCHIANTI) study, a cohort study with 3 years of follow-up.

SETTING:

Tuscany, Italy.

PARTICIPANTS:

Individuals without dementia aged 65 and older (N=652).

MEASUREMENTS:

TUP and TDP concentrations were analyzed at baseline using the Folin-Ciocalteu assay and a validated food frequency questionnaire, respectively. Cognition was assessed using the Mini-Mental State Examination (MMSE) and Trail-Making Test (TMT) at baseline and after 3 years of follow-up. Substantial cognitive decline was defined as a reduction in MMSE score of three or more points and an increase of at least 29 seconds on the TMT Part A (TMT-A) and 68 seconds on the TMT Part B (TMT-B) (the worst 10% of the distribution of decline) or as test discontinued because of multiple mistakes on the TMT A and B at follow-up.

RESULTS:

Higher TUP levels were associated with lower risk of substantial cognitive decline on the MMSE (odds ratio (OR) comparing extreme tertiles=0.53, 95% confidence interval (CI)=0.34-0.85, P-trend=.008) and on the TMT-A (OR=0.52, 95% CI=0.28-0.96, P-trend=.03), but not on TMT-B in a logistic regression model that adjusted for baseline cognitive score and potential confounding factors. TDP did not affect the development of substantial cognitive decline in either test.

CONCLUSION:

High concentrations of polyphenols, a nutritional biomarker of polyphenol intake, were associated with lower risk of substantial cognitive decline in an older population studied over a 3-year period, suggesting a protective effect against cognitive impairment.

KEYWORDS:

biomarker; cognitive decline; dietary polyphenols; epidemiology; urinary polyphenols

PMID:
25919574
PMCID:
PMC5873306
DOI:
10.1111/jgs.13379
[Indexed for MEDLINE]
Free PMC Article

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