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J Obes. 2015;2015:651460. doi: 10.1155/2015/651460. Epub 2015 Mar 30.

Long-term weight maintenance after a 17-week weight loss intervention with or without a one-year maintenance program: a randomized controlled trial.

Author information

1
Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Peijas Hospital, Sairaalakatu 1, PL 900, 00029 HUS Vantaa, Finland.
2
Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Peijas Hospital, Sairaalakatu 1, PL 900, 00029 HUS Vantaa, Finland ; Sanofi Oy, PL 22, Huopalahdentie 24, 00350 Helsinki, Finland.

Abstract

BACKGROUND:

Weight lost by obese patients is almost always regained over time. Extended treatment may improve maintenance, but solid evidence is lacking.

PURPOSE:

We determined effectiveness of maintenance therapy after a weight loss program.

METHODS:

Together 201 patients (mean age 47 years and BMI 42 kg/m(2), 71% women) were randomly assigned to either a 17-week weight loss program followed by a one-year maintenance program or to a weight loss program without subsequent maintenance intervention. The weight loss program included behavior modification and a very-low-calorie diet, and maintenance program behavior modification. The primary outcome measure was percentage of patients with 5% or more weight loss at the end of maintenance (week 69) and one year later (week 121). Secondary outcomes were weight related changes in lifestyle and quality of life.

RESULTS:

At week 69, 52% of the patients with and 44% of those without maintenance program had lost weight ≥5%, P = 0.40, and, at week 121, 33% and 34%, P = 0.77, respectively. At week 121 secondary outcomes did not differ between the groups among those successfully followed up.

CONCLUSIONS:

This one-year maintenance program was not effective in preventing weight regain in severely obese patients. Trial Registration. This trial is registered under clinicaltrials.gov Identifier: NCT00590655.

PMID:
25918644
PMCID:
PMC4396554
DOI:
10.1155/2015/651460
[Indexed for MEDLINE]
Free PMC Article

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