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J Cell Biol. 2015 Apr 27;209(2):199-210. doi: 10.1083/jcb.201410017.

Review series: The cell biology of renal filtration.

Author information

1
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 rizaldy.scott@northwestern.edu.
2
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Abstract

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.

PMID:
25918223
PMCID:
PMC4411276
DOI:
10.1083/jcb.201410017
[Indexed for MEDLINE]
Free PMC Article

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