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Mol Nutr Food Res. 2015 Jul;59(7):1400-5. doi: 10.1002/mnfr.201400820. Epub 2015 Jun 5.

Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain.

Author information

1
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
2
Institute for Bio-medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea.
3
International St. Mary's Hospital, Catholic Kwandong University, Incheon, Republic of Korea.
4
Department of Food and Nutrition, School of Foodservice Industry, Chungkang College of Cultural industries, Icheon, Republic of Korea.
5
Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju, Republic of Korea.

Abstract

Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti-inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain were employed. Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl- and aspirin-induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid-induced writhing.

KEYWORDS:

Abdominal pain; Anti-inflammatory effect; Gastritis; Kaempferol; Pancreatitis

PMID:
25917334
DOI:
10.1002/mnfr.201400820
[Indexed for MEDLINE]

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