Format

Send to

Choose Destination
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):352-9. doi: 10.5507/bp.2015.018. Epub 2015 Apr 24.

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature.

Author information

1
Department of Endocrinology, Medical University of Lublin, Poland.
2
Department of Biochemical Diagnostics, Medical University of Lublin, Poland.
3
Department of Laboratory Diagnostics, Medical University of Lublin, Poland.

Abstract

BACKGROUND:

Fetuin-A, also called Alpha 2-Heremans Schmid Glycoprotein, is a multifunctional plasma agent what has been proven in animal and human studies. It plays a role as a physiological inhibitor of insulin receptor tyrosine kinase associated with insulin resistance and a negative acute phase reactant. It also regulates bone remodeling and calcium metabolism being an important inhibitor of calcium salt precipitation and vascular calcifications.

METHODS:

PubMed database was searched for articles from 2002 up to December 2014 to identify the role of fetuin-A in the pathogenesis of selected internal diseases.

RESULTS:

Due to secretion of fetuin-A mainly by the liver, it may be a marker of liver function and predictor of mortality in patients with cirrhosis and hepatocellular cancer. The associations between high fetuin-A and metabolic syndrome as well as its hepatic manifestation- nonalcoholic fatty liver disease and atherogenic lipid profile have been well proven. However, fetuin-A relation with BMI is not so clear. Contrary to few reports, many authors suggest that fetuin-A may be an independent risk factor for type 2 diabetes and marker of diabetic complications. Close associations of high and low fetuin-A concentrations with cardiovascular diseases and mortality risk have been reported which is explained by differences in analyzed populations, stages of atherosclerosis and calcifications, coexistence of type 2 diabetes or kidney dysfunction and different main pathways of fetuin-A actions in various diseases.

CONCLUSIONS:

Fetuin-A has a diagnostic potential as a biomarker for liver dysfunction, cardiovascular diseases and disorders associated with metabolic syndrome.

KEYWORDS:

atherosclerosis; cardiovascular disease; diabetes; fetuin-A; obesity

PMID:
25916279
DOI:
10.5507/bp.2015.018
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Palacky University Olomouc
Loading ...
Support Center