Format

Send to

Choose Destination
Brain Inj. 2015;29(7-8):866-71. doi: 10.3109/02699052.2015.1005133. Epub 2015 Apr 27.

Troublesome heterotopic ossification and stroke: Features and risk factors. A case control study.

Author information

1
Department of Physical Medicine and Rehabilitation, Hôpital Raymond Poincaré , Garches , France .

Abstract

PRIMARY OBJECTIVE:

To determine the features of stroke-related HO in a large sample of patients and to assess if HO risk is increased by haemorrhagic stroke.

RESEARCH DESIGN:

A case control study (risk factor of a rare event using retrospective analysis).

METHODS AND PROCEDURES:

Sixty-one patients with stroke-81 troublesome HOs-were included, each was matched with four controls, i.e. 244 patients with no HO after stroke. Matching criteria were age (±3.5 years) and sex. Data recorded were time from stroke to surgery, ischaemic or haemorrhagic stroke and presence of HO risk factors.

MAIN OUTCOMES AND RESULTS:

Mean age at time of stroke = 46.02 ± 11.4 years (15.9-76.3) for the case sub-group. Time from stroke to surgery = 23.4 ± 27.8 months (3.6-150.0). There was a significant relationship between haemorrhagic stroke and HO development (OR = 3.01; 95% CI = 1.14-7.98; p < 0.05), but not for ischaemic stroke. This became non-significant when all matching and risk factors were included in the model (adjusted OR = 1.98; 95% CI = 0.60-6.54; p = 0.26).

CONCLUSION:

Haemorrhagic stroke appears to increase the risk of HO development. Further studies are required to determine if this risk factor is independent from other comorbid factors.

KEYWORDS:

Epidemiology; hemiplegic; heterotopic ossification; stroke

PMID:
25915823
DOI:
10.3109/02699052.2015.1005133
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center