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Trends Microbiol. 2015 Jun;23(6):330-1. doi: 10.1016/j.tim.2015.04.003. Epub 2015 Apr 23.

Novel role of DNA in neutrophil extracellular traps.

Author information

1
Institute for Bacteriology and Mycology, Centre for Infectious Diseases, College of Veterinary Medicine, University Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany.
2
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany. Electronic address: mkoeckbl@tiho-hannover.de.

Abstract

Neutrophil extracellular traps (NETs) have been shown to play a crucial role in health and disease. In a recent paper in PLoS Pathogens, Halverson et al. demonstrate that the DNA backbone of NETs contributes to its antibacterial activity and serves as signal for entrapped microbes to employ immune evasion strategies.

KEYWORDS:

DNA; Pseudomonas aeruginosa; Staphylococcus aureus; antimicrobial activity; neutrophils

PMID:
25913613
DOI:
10.1016/j.tim.2015.04.003
[Indexed for MEDLINE]

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