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Trends Microbiol. 2015 Aug;23(8):479-89. doi: 10.1016/j.tim.2015.03.010. Epub 2015 Apr 24.

Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1.

Author information

1
Department of Pharmacy, School of Pharmacy, Hanyang University, Ansan 426-791, Korea; Institute of Pharmacological Research, Hanyang University, Ansan 426-791, Korea.
2
Rajiv Gandhi Centre for Biotechnology, Thycaud P.O., Trivandrum 695 014, Kerala, India.
3
Department of Pharmacy, School of Pharmacy, Hanyang University, Ansan 426-791, Korea; Institute of Pharmacological Research, Hanyang University, Ansan 426-791, Korea. Electronic address: dongwook@hanyang.ac.kr.

Abstract

The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.

KEYWORDS:

Vibrio cholerae; cholera; cholera toxin; phage CTX

PMID:
25913612
DOI:
10.1016/j.tim.2015.03.010
[Indexed for MEDLINE]

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