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Curr Biol. 2015 May 18;25(10):1270-81. doi: 10.1016/j.cub.2015.03.027. Epub 2015 Apr 23.

Sleep restores behavioral plasticity to Drosophila mutants.

Author information

1
Department of Anatomy and Neurobiology, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
2
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
3
Centre for Neural Circuits and Behaviour, University of Oxford, Oxford 1 3SR, UK.
4
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey 2 7XH, UK.
5
Department of Anatomy and Neurobiology, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: shawp@pcg.wustl.edu.

Abstract

Given the role that sleep plays in modulating plasticity, we hypothesized that increasing sleep would restore memory to canonical memory mutants without specifically rescuing the causal molecular lesion. Sleep was increased using three independent strategies: activating the dorsal fan-shaped body, increasing the expression of Fatty acid binding protein (dFabp), or by administering the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP). Short-term memory (STM) or long-term memory (LTM) was evaluated in rutabaga (rut) and dunce (dnc) mutants using aversive phototaxic suppression and courtship conditioning. Each of the three independent strategies increased sleep and restored memory to rut and dnc mutants. Importantly, inducing sleep also reverses memory defects in a Drosophila model of Alzheimer's disease. Together, these data demonstrate that sleep plays a more fundamental role in modulating behavioral plasticity than previously appreciated and suggest that increasing sleep may benefit patients with certain neurological disorders.

PMID:
25913403
PMCID:
PMC4465363
DOI:
10.1016/j.cub.2015.03.027
[Indexed for MEDLINE]
Free PMC Article

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