Format

Send to

Choose Destination
Neurobiol Dis. 2015 Dec;84:78-83. doi: 10.1016/j.nbd.2015.04.002. Epub 2015 Apr 22.

Vitamin E and neurodegeneration.

Author information

1
Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
2
Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: dxm178@case.edu.

Abstract

Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative damage and motor coordination deficits. We review here the established roles of vitamin E in protecting cerebellar functions, as well as emerging data demonstrating the critical roles of alpha-tocopherol in preserving learning, memory and emotive responses. We also discuss the importance of vitamin E adequacy in seemingly unrelated neurological disorders.

KEYWORDS:

Anxiety; Cerebellum; Memory; Neurodegeneration; Tocopherol; Vitamin E

PMID:
25913028
DOI:
10.1016/j.nbd.2015.04.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center