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Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):1-11. doi: 10.9758/cpn.2015.13.1.1.

Tobacco use in bipolar disorder.

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Department of Applied Sciences, RMIT, Bundoora.
IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong.
Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Department of Psychiatry, University of Melbourne, Parkville, Australia.
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia.
Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Maranon, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain.
Research Unit, Mental Health Services, Region of Southern Denmark, Esbjerg, Denmark.
Centre for Mental Health and Wellbeing Research, School of Psychology, Deakin University, Burwood, Australia.


Tobacco use in mental health in general and bipolar disorder in particular remains disproportionally common, despite declining smoking rates in the community. Furthermore, interactions between tobacco use and mental health have been shown, indicating the outcomes for those with mental health disorders are impacted by tobacco use. Factors need to be explored and addressed to improve outcomes for those with these disorders and target specific interventions for people with psychiatric illness to cease tobacco smoking. In the context of bipolar disorder, this review explores; the effects of tobacco smoking on symptoms, quality of life, suicidal behavior, the biological interactions between tobacco use and bipolar disorder, the interactions between tobacco smoking and psychiatric medications, rates and factors surrounding tobacco smoking cessation in bipolar disorder and suggests potential directions for research and clinical translation. The importance of this review is to bring together the current understanding of tobacco use in bipolar disorder to highlight the need for specific intervention.


Bipolar disorder; Psychotropic drugs; Quality of life; Smoking; Smoking cessation

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