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Semin Immunol. 2015 Mar;27(2):75-84. doi: 10.1016/j.smim.2015.03.009. Epub 2015 Apr 22.

PRR-signaling pathways: Learning from microbial tactics.

Author information

1
Department of Medicine III, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
2
Institute of Nutritional Medicine, Department of Immunology, University of Hohenheim, Fruwirthstr. 12, 70599 Stuttgart, Germany. Electronic address: thomas.kufer@uni-hohenheim.de.

Abstract

Recognition of bacterial pathogens by the mammalian host relies on the induction of early innate immune responses initiated by the activation of pattern-recognition receptors (PRRs) upon sensing of their cognate microbe-associated-patterns (MAMPs). Successful pathogens have evolved to intercept PRR activation and signaling at multiple steps. The molecular dissection of the underlying mechanisms revealed many of the basic mechanisms used by the immune system. Here we provide an overview of the different strategies used by bacterial pathogens and commensals to subvert and reprogram PPR-mediated innate immune responses. A particular attention is given to recent discoveries highlighting novel molecular details of the host inflammatory response in mammalian cells and current advances in our understanding of the interaction of commensals with PRR-mediated responses.

KEYWORDS:

Actin; Inflammation; Kinase; NLR; Signaling; T3SS; TLR

PMID:
25911384
DOI:
10.1016/j.smim.2015.03.009
[Indexed for MEDLINE]

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