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Neurobiol Aging. 2015 Jun;36(6):2184-5. doi: 10.1016/j.neurobiolaging.2015.03.014. Epub 2015 Apr 2.

Should they team up to make your brain clock?

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Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic. Electronic address:


Large-conductance calcium-activated potassium channels (BK channels) are important regulators of neuronal excitability in the mammalian nervous system. BK channels are activated by changes in membrane electrical potential and intracellular calcium concentration and play a key role in shaping neuronal action potential. Indeed, under typical physiological conditions, opening of BK channels allows potassium ions to flow outside of the cell leading to membrane repolarization and fast afterhyperpolarization, thus controlling cellular excitability. These aspects are of direct relevance to a new study by Farajnia et al., 2015, reported in this issue of Neurobiology of Aging, on the role of BK channels in aging circadian clock neurons.


Aging; BK channel; Calcium channel; Circadian rhythm; Potassium channel; SCN neuron; T-type channel

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