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J Magn Reson. 2015 Jun;255:34-8. doi: 10.1016/j.jmr.2015.03.004. Epub 2015 Mar 23.

Optimized selective lactate excitation with a refocused multiple-quantum filter.

Author information

1
Experimental Physics III, TU Dortmund University, 44227 Dortmund, Germany. Electronic address: mirjam.holbach@tu-dortmund.de.
2
Leibniz Institut für Analytische Wissenschaften - ISAS e.V., 44139 Dortmund, Germany.
3
Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141 Essen, Germany.
4
Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141 Essen, Germany; Medical Physics in Radiology, German Cancer Research Center, 69120 Heidelberg, Germany.
5
Experimental Physics III, TU Dortmund University, 44227 Dortmund, Germany.

Abstract

Selective detection of lactate signals in in vivo MR spectroscopy with spectral editing techniques is necessary in situations where strong lipid or signals from other molecules overlap the desired lactate resonance in the spectrum. Several pulse sequences have been proposed for this task. The double-quantum filter SSel-MQC provides very good lipid and water signal suppression in a single scan. As a major drawback, it suffers from significant signal loss due to incomplete refocussing in situations where long evolution periods are required. Here we present a refocused version of the SSel-MQC technique that uses only one additional refocussing pulse and regains the full refocused lactate signal at the end of the sequence.

KEYWORDS:

Lactate editing; MRS; Multiple-quantum filter; Refocused SSel-MQC

PMID:
25909643
DOI:
10.1016/j.jmr.2015.03.004

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