White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?

Stroke. 2015 Jun;46(6):1707-9. doi: 10.1161/STROKEAHA.115.009090. Epub 2015 Apr 23.

Abstract

Background and purpose: We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography-based amyloid-β burden across a wide range of cerebrovascular amyloid deposition.

Methods: Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects≥60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography. CSO-PVS was evaluated on T2-magnetic resonance imaging using a 4-point scale. The association between Pittsburgh compound B and CSO-PVS was assessed in linear regression.

Results: In multivariable analyses adjusted for age, microbleeds and white matter hyperintensities, whole cortex Pittsburgh compound B binding was associated with CSO-PVS degree both as continuous (coefficient, 0.11; 95% confidence interval, 0.01-0.22; P=0.040) and as dichotomous variable (coefficient, 0.27; 95% confidence interval, 0.11-0.44; P=0.002). The median Pittsburgh compound B retention was higher in high versus low CSO-PVS degree (P=0.0007).

Conclusions: This pilot study suggests a possible association between cerebrovascular amyloid deposition and CSO-PVS, with potential pathophysiological implications.

Keywords: cerebral amyloid angiopathy.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amyloid beta-Peptides / metabolism*
  • Aniline Compounds / administration & dosage
  • Biomarkers / metabolism
  • Cerebral Amyloid Angiopathy* / diagnostic imaging
  • Cerebral Amyloid Angiopathy* / metabolism
  • Cerebral Angiography*
  • Female
  • Humans
  • Magnetic Resonance Angiography*
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Thiazoles / administration & dosage
  • White Matter* / diagnostic imaging
  • White Matter* / metabolism

Substances

  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid beta-Peptides
  • Aniline Compounds
  • Biomarkers
  • Thiazoles