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Nat Rev Cancer. 2015 May;15(5):311-6. doi: 10.1038/nrc3944.

Examining the utility of patient-derived xenograft mouse models.

Author information

1
Department of Pathology and Laboratory Medicine, University of British Columbia, and BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, British Columbia, Canada.
2
Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
3
Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA.

Abstract

Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.

PMID:
25907221
DOI:
10.1038/nrc3944
[Indexed for MEDLINE]
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