Format

Send to

Choose Destination
Acta Radiol. 2016 Apr;57(4):487-93. doi: 10.1177/0284185115581541. Epub 2015 Apr 22.

The value of anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recurrent prostate carcinoma: a meta-analysis.

Author information

1
Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
2
Department of Nuclear Medcine, Jin Hua Municipal Central Hospital, Zhe Jiang, PR China 13681221974@163.com.
3
Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China helenscu@163.com.

Abstract

BACKGROUND:

Anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC) positron emission tomography/computed tomography (PET/CT), 11 C-choline PET/CT, 111In-capromab pendetide, and T2-weighted magnetic resonance imaging (MRI) have been used for detecting prostate carcinoma relapse.

PURPOSE:

To systematically review and perform a meta-analysis of published data regarding the performance of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma.

MATERIAL AND METHODS:

A comprehensive review of the literature regarding the role of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma was performed. Pooled sensitivity, specificity, and the area under the receiver-operating characteristic of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma were calculated based on the included studies.

RESULTS:

Six studies comprising 251 patients, suspicious of prostate carcinoma recurrence, were included in this meta-analysis. 18F-FACBC PET/CT had an 87% pooled sensitivity, 66% pooled specificity, 0.93 the area under the receiver-operating characteristic curve on a per patient-based analysis in detecting prostate carcinoma recurrence.

CONCLUSION:

18F-FACBC PET/CT was a non-invasive, metabolic imaging technique in the diagnosis of prostate carcinoma relapse.

KEYWORDS:

PET/CT; Prostate carcinoma; anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC); recurrence

PMID:
25907118
DOI:
10.1177/0284185115581541
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center