Format

Send to

Choose Destination
MMWR Morb Mortal Wkly Rep. 2015 Apr 24;64(15):421-3.

Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines.

Abstract

Neural tube defects (NTDs) such as spina bifida, anencephaly, and encephalocele are serious birth defects of the brain and spine that occur during the first month of pregnancy when the neural tube fails to close completely. Randomized controlled trials and observational studies have shown that adequate daily consumption of folic acid before and during early pregnancy considerably reduces the risk for NTDs. The U.S. Public Health Service recommends that women capable of becoming pregnant consume 400 µg of folic acid daily for NTD prevention. Furthermore, fortification of staple foods (e.g., wheat flour) with folic acid has decreased folate-sensitive NTD prevalence in multiple settings and is a highly cost-effective intervention.

PMID:
25905896
PMCID:
PMC5779552
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC - Morbidity and Mortality Weekly Report Icon for PubMed Central
Loading ...
Support Center