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Iran J Public Health. 2015 Feb;44(2):176-84.

Use of noninsulin anti diabetics for prevention and treatment of cancer- narrative review article.

Author information

1
Dept. of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Abstract

BACKGROUND:

Epidemiological evidence shows that cancer and diabetes are major causes of death in the world. Type2 diabetes increases the risk of cancer-specific mortality. This review relates diabetic therapies, diabetes and cancer.

METHOD:

All published papers in this field were searched, looking into such databases as Science Direct, ISI Web of Knowledge, PubMed and Scopus.

RESULTS:

In cancer patients, metformin improves patient outcome and reduces cancer risk. Sulfonylureas may increase risk of cancer, but decreased risk of cancer is associated with thiazolidinediones in type 2 diabetic subjects. Metformin lowers circulating insulin and it may be important for treatment of hyperinsulinemia-associated cancers, such as colon and breast cancer.

CONCLUSION:

However, laboratory investigations and large-scale population based studies are required for further investigation of association of cancer-preventive, anti-cancer and cancer-mortality of noninsulin antidiabetics.

KEYWORDS:

Diabetes; Hyperinsulinemia; Malignant; Metformin hyperinsulinemia; Mortality; Thiazolidinediones

PMID:
25905051
PMCID:
PMC4401875

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