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Med Gas Res. 2014 Nov 8;4:17. doi: 10.1186/2045-9912-4-17. eCollection 2014.

A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.

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Department of Emergency, Shanghai Provincial Crops Hospital, Chinese People's Armed Police Forces, 831HongXu Road, Shanghai, 201103 PR China.
Department of Quality Management, General Hospital, Chinese Armed Police Force, 69YongDing Road, Beijing, 100039 PR China.
Department of Medical Abministration, General Hospital, Chinese Armed Police Force, 69YongDing Road, Beijing, 100039 PR China.
Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, 800XiangYin Road, Shanghai, 200433 PR China.


Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflammatory agent and so may have potential medical applications in cells, tissues and organs. There are several methods to administer hydrogen, such as inhalation of hydrogen gas, aerosol inhalation of a hydrogen-rich solution, drinking hydrogen dissolved in water, injecting hydrogen-rich saline (HRS) and taking a hydrogen bath. Drinking hydrogen solution (saline/pure water/other solutions saturated with hydrogen) may be more practical in daily life and more suitable for daily consumption. This review summarizes the findings of recent studies on the use of hydrogen in emergency and critical care medicine using different disease models.


Antioxidant; Critical care medicine; Emergency; Hydrogen; Reactive oxygen species

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