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J Antimicrob Chemother. 2015 Aug;70(8):2255-60. doi: 10.1093/jac/dkv100. Epub 2015 Apr 22.

Antimicrobial activity and skin permeation of iodine present in an iodine-impregnated surgical incise drape.

Author information

1
Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2WB, UK.
2
Wolfson Computer Laboratory, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.
3
Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
4
Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2WB, UK tom.elliott@uhb.nhs.uk.

Abstract

OBJECTIVES:

The antimicrobial efficacy of an iodine-impregnated incise drape against MRSA was evaluated in a skin model. The permeation of iodine from this drape into the skin was also assessed.

METHODS:

The antimicrobial efficacy was evaluated in ex vivo studies following application of the surgical incise drape for various times on the surface of donor skin, which was inoculated with either 1 × 10(3) or 1 × 10(6) cfu MRSA/cm(2) skin and mounted on Franz diffusion cells. In some experiments the MRSA-inoculated skin was pre-incubated for 18 h at room temperature prior to applying the drape. Permeation of iodine into the skin using this model was also determined following application of the incise drape for 6 h.

RESULTS:

The iodine-impregnated drape demonstrated antimicrobial activity compared with the non-use of drape. This reached significance when a high inoculum of MRSA was applied with no pre-incubation period and when a low inoculum of MRSA was applied with a pre-incubation period (P = 0.002 and P = 0.014, respectively). Furthermore, in experiments wherein a high inoculum of MRSA was applied with no pre-incubation period, the iodine-impregnated drape demonstrated superior antimicrobial activity compared with the use of a non-antimicrobial drape (P < 0.001). MIC and MBC values of iodine were attained to 1500 μm below the skin surface.

CONCLUSIONS:

The iodine-impregnated surgical incise drape had detectable antimicrobial activity. Furthermore, iodine penetrated into the deeper layers of the skin. This property should suppress microbial regrowth at and around a surgical incision site, making its use preferable to the use of a standard drape or non-use of a drape.

KEYWORDS:

antiseptics; infection control; surgical infections

PMID:
25904727
DOI:
10.1093/jac/dkv100
[Indexed for MEDLINE]

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