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Nature. 2015 Apr 23;520(7548):474-482. doi: 10.1038/nature14436.

Evolution of vertebrates as viewed from the crest.

Author information

1
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
#
Contributed equally

Abstract

The origin of vertebrates was accompanied by the advent of a novel cell type: the neural crest. Emerging from the central nervous system, these cells migrate to diverse locations and differentiate into numerous derivatives. By coupling morphological and gene regulatory information from vertebrates and other chordates, we describe how addition of the neural-crest-specification program may have enabled cells at the neural plate border to acquire multipotency and migratory ability. Analysis of the topology of the neural crest gene regulatory network can serve as a useful template for understanding vertebrate evolution, including elaboration of neural crest derivatives.

PMID:
25903629
PMCID:
PMC5100666
DOI:
10.1038/nature14436
[Indexed for MEDLINE]
Free PMC Article

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